Structure elucidation of new monordens produced by Humicola sp. FO-2942.
نویسندگان
چکیده
Structures of three novel compounds designated monordens C to E, isolated from the fermentation broth of amidepsine-producing fungus Humicola sp. FO-2942, were elucidated by spectroscopic evidence. Monordens C is 6,7-dihydromonorden A. Monordens D and E lack the epoxide moiety of monordens C and B, respectively.
منابع مشابه
Xanthoquinodins, new anticoccidial agents produced by Humicola sp. Production, isolation and physico-chemical and biological properties.
Humicola sp. FO-888, a soil isolate, was found to produce a series of new anticoccidial compounds. Five active compounds, designated xanthoquinodins A1, A2, A3, B1 and B2 were isolated from the fermentation broth of the producing strain by solvent extraction and HPLC. Xanthoquinodins inhibited the growth of Eimeria tenella in an in vitro assay system using BHK-21 cells as a host. No schizont in...
متن کاملKurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis.
The structures of new protein farnesyltransferase inhibitors, kurasoins A and B, were elucidated by NMR study. Kurasoins A and B are acyloin compounds having in common a 3-hydroxy-1-phenyl-2-butanone moiety, to which p-hydroxyphenyl and 3-indolyl moieties respectively, are connected at C-4. The structures were confirmed by total synthesis.
متن کاملAndrastin D, novel protein farnesyltransferase inhibitor produced by Penicillium sp. FO-3929.
androstane skeleton with a keto-enol tautomerism at the cyclopentane ring. Wecarried out further isolation for PFTase inhibitors from the cultured broth of strain FO-3929 and found andrastin D (4, Fig. 1). In this paper, fermentation, isolation, structure elucidation, and biological properties of 4 are described. A stock culture of strain FO-3929 was inoculated into six 500-ml Erlenmeyer flasks...
متن کاملIsolation and structure elucidation of five new asterriquinones from Aspergillus, Humicola and Botryotrichum species.
Five new quinone pigments have been discovered from the fermentation broth of Aspergillus, Humicola and Botryotrichum species isolated from different soil samples. These compounds inhibit serine proteases of the coagulation pathway. Their structures which differ in the identity and position of a 5-carbon side chain on the indole moiety have been elucidated based on NMR and FAB-MS experiments.
متن کاملWF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea.
WF-2421 is a novel aldose reductase inhibitor produced by Humicola grisea. WF-2421 was purified from the culture filtrate by successive ion exchange chromatography and the chemical structure was assigned to be alpha-formamido-5'-(2-formamido-1-hydroxyethyl)- beta,2',6-trihydroxy-3-biphenylpropanoic acid (1) on the basis of spectroscopic evidence. The IC50 value of WF-2421 was 3 x 10(-8) M again...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of antibiotics
دوره 56 6 شماره
صفحات -
تاریخ انتشار 2003